Title |
Effects of the administration of pentoxifylline and prednisolone on the evolution of portal fibrogenesis secondary to biliary obstruction in growing animals: immunohistochemical analysis of the expression of TGF- β and VEGF
|
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Published in |
Clinics, January 2012
|
DOI | 10.6061/clinics/2012(12)17 |
Pubmed ID | |
Authors |
Wagner de Castro Andrade, Luiz Fernando Ferraz da Silva, Maria Cecilia de Mendonça Coelho, Ana Cristina Aoun Tannuri, Venancio Avancini Ferreira Alves, Uenis Tannuri |
Abstract |
During the neonatal and infancy periods, some chronic liver diseases may lead to progressive hepatic fibrosis, which is a condition that can ultimately result in the loss of organ function and severe portal hypertension necessitating hepatic transplantation. In a previous report, pharmacological interventions were demonstrated to modulate hepatic fibrosis induced by bile duct ligation in young rats. The administration of pentoxifylline or prednisolone, or the combination of both, resulted in reduced fibrogenesis in portal spaces. The objectives of the present study were to evaluate the expression of transforming growth factor β and vascular endothelial growth factor after bile duct ligation in young rats and to assess the effect of those same drugs on cytokine expression. |
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Demographic breakdown
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