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Oxidative stress and immune system analysis after cycle ergometer use in critical patients

Overview of attention for article published in Clinics, March 2017
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  • Good Attention Score compared to outputs of the same age (65th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (57th percentile)

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Title
Oxidative stress and immune system analysis after cycle ergometer use in critical patients
Published in
Clinics, March 2017
DOI 10.6061/clinics/2017(03)03
Pubmed ID
Authors

Eduardo Eriko Tenório de França, Luana Carneiro Ribeiro, Gabriela Gomes Lamenha, Isabela Kalline Fidelix Magalhães, Thainá de Gomes Figueiredo, Marthley José Correia Costa, Ubiracé Fernando Elihimas Júnior, Bárbara Luana Feitosa, Maria do Amparo Andrade, Marco Aurélio Valois Correia Júnior, Francimar Ferrari Ramos, Célia Maria Machado Barbosa de Castro

Abstract

The passive cycle ergometer aims to prevent hypotrophy and improve muscle strength, with a consequent reduction in hospitalization time in the intensive care unit and functional improvement. However, its effects on oxidative stress and immune system parameters remain unknown. The aim of this study is to analyze the effects of a passive cycle ergometer on the immune system and oxidative stress in critical patients. This paper describes a randomized controlled trial in a sample of 19 patients of both genders who were on mechanical ventilation and hospitalized in the intensive care unit of the Hospital Agamenom Magalhães. The patients were divided into two groups: one group underwent cycle ergometer passive exercise for 30 cycles/min on the lower limbs for 20 minutes; the other group did not undergo any therapeutic intervention during the study and served as the control group. A total of 20 ml of blood was analysed, in which nitric oxide levels and some specific inflammatory cytokines (tumour necrosis factor alpha (TNF-α), interferon gamma (IFN-γ) and interleukins 6 (IL-6) and 10 (IL-10)) were evaluated before and after the study protocol. Regarding the demographic and clinical variables, the groups were homogeneous in the early phases of the study. The nitric oxide analysis revealed a reduction in nitric oxide variation in stimulated cells (p=0.0021) and those stimulated (p=0.0076) after passive cycle ergometer use compared to the control group. No differences in the evaluated inflammatory cytokines were observed between the two groups. We can conclude that the passive cycle ergometer promoted reduced levels of nitric oxide, showing beneficial effects on oxidative stress reduction. As assessed by inflammatory cytokines, the treatment was not associated with changes in the immune system. However, further research in a larger population is necessary for more conclusive results.

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The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 212 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 212 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 33 16%
Student > Bachelor 26 12%
Researcher 19 9%
Student > Ph. D. Student 15 7%
Student > Postgraduate 14 7%
Other 31 15%
Unknown 74 35%
Readers by discipline Count As %
Nursing and Health Professions 42 20%
Medicine and Dentistry 41 19%
Sports and Recreations 10 5%
Social Sciences 6 3%
Agricultural and Biological Sciences 5 2%
Other 19 9%
Unknown 89 42%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 January 2018.
All research outputs
#7,208,166
of 25,382,440 outputs
Outputs from Clinics
#267
of 1,215 outputs
Outputs of similar age
#109,606
of 324,443 outputs
Outputs of similar age from Clinics
#3
of 7 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 1,215 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.2. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 324,443 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.