Title |
Plasmid-mediated mcr-1 in carbapenem-susceptible Escherichia coli ST156 causing a blood infection: an unnoticeable spread of colistin resistance in Brazil?
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Published in |
Clinics, October 2017
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DOI | 10.6061/clinics/2017(10)09 |
Pubmed ID | |
Authors |
Flavia Rossi, Raquel Girardello, Carlos Morais, Ana Paula Cury, Layla Farage Martins, Aline Maria da Silva, Edson Abdala, João Carlos Setubal, Alberto José da Silva Duarte |
Abstract |
We describe an IncX4 pHC891/16mcr plasmid carrying mcr-1 in a colistin-resistant and carbapenem-susceptible E. coli isolate (HC891/16), ST156, which caused a blood infection in a Brazilian patient with gallbladder adenocarcinoma. Strain HC891/16 was subjected to whole genome sequencing using the MiSeq Platform (Illumina, Inc., USA). Assembly was performed using Mira and ABACAS. The isolates showed resistance only to ciprofloxacin, ampicillin and cefoxitin, and whole-genome sequencing revealed the presence of aac(6')Ib-cr and blaTEM1. Our findings warn of the possible silent dissemination of colistin resistance by carbapenem-susceptible mcr-1 producers, as colistin susceptibility is commonly tested only among carbapenem-resistant isolates. |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 44 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 13 | 30% |
Student > Doctoral Student | 4 | 9% |
Researcher | 4 | 9% |
Student > Ph. D. Student | 4 | 9% |
Student > Bachelor | 3 | 7% |
Other | 4 | 9% |
Unknown | 12 | 27% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 9 | 20% |
Agricultural and Biological Sciences | 7 | 16% |
Biochemistry, Genetics and Molecular Biology | 6 | 14% |
Immunology and Microbiology | 5 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 5% |
Other | 4 | 9% |
Unknown | 11 | 25% |