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Changes in the intestinal microbiota of superobese patients after bariatric surgery

Overview of attention for article published in Clinics, October 2019
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Title
Changes in the intestinal microbiota of superobese patients after bariatric surgery
Published in
Clinics, October 2019
DOI 10.6061/clinics/2019/e1198
Pubmed ID
Authors

Denis Pajecki, Lea Campos de Oliveira, Ester Cerdeira Sabino, Marcela de Souza-Basqueira, Anna Carolina Batista Dantas, Gabriel Cairo Nunes, Roberto de Cleva, Marco Aurélio Santo

Abstract

The gut microbiota is associated with obesity and weight loss after bariatric surgery and has been related to its changing pattern. Exactly how the bacterial population affects weight loss and the results of surgery remain controversial. This study aimed to evaluate the intestinal microbiota of superobese patients before and after gastric bypass surgery (RYGB). DNA fragments for the microbiota obtained from stool samples collected from nine superobese patients before and after bariatric surgery were sequenced using Ion Torrent. We observed that with a mean follow-up of 15 months, patients achieved 55.9% excess weight loss (EWL). A significant population reduction in the Proteobacteria phylum (11 to 2%, p=0.0025) was observed after surgery, while no difference was seen in Firmicutes and Bacteroidetes. Further analyses performed with two specific individuals with divergent clinical outcomes showed a change in the pattern between them, with a significant increase in Firmicutes and a decrease in Bacteroidetes in the patient with less weight loss (%EWL 50.79 vs. 61.85). RYGB affects the microbiota of superobese patients, with a significant reduction in Proteobacteria in patients with different weight loss, showing that different bacteria may contribute to the process.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 63 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 63 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 7 11%
Student > Ph. D. Student 5 8%
Student > Master 5 8%
Other 4 6%
Researcher 4 6%
Other 11 17%
Unknown 27 43%
Readers by discipline Count As %
Medicine and Dentistry 16 25%
Nursing and Health Professions 5 8%
Biochemistry, Genetics and Molecular Biology 4 6%
Unspecified 1 2%
Business, Management and Accounting 1 2%
Other 4 6%
Unknown 32 51%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 November 2019.
All research outputs
#19,954,338
of 25,387,668 outputs
Outputs from Clinics
#824
of 1,215 outputs
Outputs of similar age
#271,986
of 376,809 outputs
Outputs of similar age from Clinics
#15
of 24 outputs
Altmetric has tracked 25,387,668 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,215 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.2. This one is in the 29th percentile – i.e., 29% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 376,809 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.