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Role of Reactive Oxygen Species and Advanced Glycation End Products in the Malfunctioning of Dental Implants.

Overview of attention for article published in West Indian Medical Journal, July 2015
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Title
Role of Reactive Oxygen Species and Advanced Glycation End Products in the Malfunctioning of Dental Implants.
Published in
West Indian Medical Journal, July 2015
DOI 10.7727/wimj.2014.105
Pubmed ID
Authors

M Guo, L Liu, J Zhang, M Liu

Abstract

In the last decade, dental implants have emerged as a crucial modality and serve as an individual form of therapy for dental failure. However, disparities in host responses have led to peri-implantitis and implant failure. The pathological mechanisms driving peri-implantitis remain largely unknown. In this study, we evaluated the role of oxidative stress and advanced glycation end products (AGE) in the progression of peri-implantitis and dental implants failure and compared with chronic periodontal disease. Three patient groups (peri-implantitis, chronic periodontal disease and control), each with 10 subjects (7M/3F) and average age ranging from 40-60 years were selected for analysis. Salivary oxidative stress and tissue AGE levels were analysed by probing for reactive oxygen species (ROS) and Maillard reaction-related fluorescence, respectively. We observed significant increase (> 2-fold) in oxidative stress and AGE levels in patients with peri-implantitis and chronic periodontal disease compared to controls, with chronic periodontal disease having the highest levels. In addition, we observed a strong positive correlation (r = 0.94) between oxidative stress and AGE levels in the patients. We propose that increased AGE levels and oxidative stress, although not the only pathway, is a significant mediator in the pathogenesis of peri-implantitis. Altering them may potentially be used in combination with other modalities to manage peri-implantitis.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 39 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 6 15%
Researcher 5 13%
Student > Postgraduate 4 10%
Student > Master 4 10%
Student > Ph. D. Student 3 8%
Other 5 13%
Unknown 12 31%
Readers by discipline Count As %
Medicine and Dentistry 17 44%
Engineering 3 8%
Business, Management and Accounting 2 5%
Materials Science 2 5%
Social Sciences 1 3%
Other 2 5%
Unknown 12 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 February 2016.
All research outputs
#17,239,390
of 25,377,790 outputs
Outputs from West Indian Medical Journal
#118
of 224 outputs
Outputs of similar age
#163,890
of 276,200 outputs
Outputs of similar age from West Indian Medical Journal
#4
of 7 outputs
Altmetric has tracked 25,377,790 research outputs across all sources so far. This one is in the 31st percentile – i.e., 31% of other outputs scored the same or lower than it.
So far Altmetric has tracked 224 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 276,200 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.