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Mendeley readers
| Title |
Simvastatin Protects Osteoblasts from the Deleterious Effects of the Liquid Milieu of Multiple Myeloma.
|
|---|---|
| Published in |
West Indian Medical Journal, April 2016
|
| DOI | 10.7727/wimj.2014.227 |
| Pubmed ID | |
| Authors |
R Jitumori, D Fernandes, C Jitumori, G M Favero |
| Abstract |
Lytic bone lesions are the main clinical manifestation of multiple myeloma. The intense variety in this cell microenvironment, composed mainly of fibroblasts, osteoblasts, osteoclasts, immune cells and mesenchymal cells, is influenced by the massive presence of neoplastic plasma cells. Studies with statins have reported their action in stimulating the formation and reducing bone resorption. The aim of this study was to verify the in vitro response of human osteoblasts exposed to the supernatant (liquid melieu) of multiple myeloma. The data obtained indicate that simvastin has positive effects on the growth of osteoblasts and protection against the anti-proliferative effects of multiple myeloma supernatant. |
Mendeley readers
The data shown below were compiled from readership statistics for 4 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 25% |
| Unknown | 3 | 75% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 1 | 25% |
| Student > Bachelor | 1 | 25% |
| Researcher | 1 | 25% |
| Other | 1 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Nursing and Health Professions | 1 | 25% |
| Materials Science | 1 | 25% |
| Medicine and Dentistry | 1 | 25% |
| Unknown | 1 | 25% |