https://t.co/FSHtyEb6jb "Conclusions: BRCA mutations significantly co-occur with TP53 mutations. After adjusting for BRCA mutations, TP53 mutations are associated with platinum sensitivity, and this effect is not dependent on TP53 mutation type."
Dr. Ghezelayagh found TP53 mutations are ubiquitous in BRCA mutated ovarian cancers and are present in most but significantly fewer high grade serous OCs not associated with BRCA mutations. @UWMedicine @SwisherLab
Fellow Dr. Talayeh Ghezelayagh with @KPenningtonMD @BarbNorquist @SwisherLiz and team: "Characterizing TP53 mutations in ovarian carcinomas with and without concurrent BRCA1 or BRCA2 mutations" in Gynecologic Oncology. https://t.co/8SlA5qhfDk @SwisherLa…