The insulin-like growth factor (IGF)-axis may be implicated in glucose homeostasis, but its longitudinal profile across gestation in relation to the development of gestational diabetes (GDM) is largely unknown. We prospectively investigated IGF-axis biomarkers in early-to-mid pregnancy in relation to subsequent GDM risk in a case-control study of 107 GDM cases and 214 non-GDM controls, with blood samples collection at gestational weeks (GW) 10-14, 15-26, 23-31, and 33-39. Conditional logistic regression was used, adjusting for major risk factors including pre-pregnancy body mass index. Plasma IGF-I and IGF-binding protein (BP)-3 concentrations and IGF-I/IGFBP-3 molar ratio increased whereas IGFBP-2 decreased throughout pregnancy. At GW 10-14, both IGF-I and IGF-I/IGFBP-3 were positively associated with GDM risk; adjusted odds ratio comparing the highest vs. lowest quartile (ORQ4-Q1) was 2.93 (95% confidence interval 1.18-7.30) for IGF-I and 3.31 (1.10-9.98) for IGF-I/IGFBP-3. In contrast, higher IGFBP-2 levels were related to a substantially lower risk of GDM (ORQ4-Q1 0.04, 0.01-0.06). Similar results were observed at GW 15-26. In sum, the IGF-axis, IGFBP-2 in particular, may be implicated in the pathogenesis of GDM with significant associations and incremental predictive value detected as early as GW 10-14, approximately 10-18 weeks earlier before GDM is typically screened for.
Pharmacology, Toxicology and Pharmaceutical Science
1
2%
Other
2
4%
Unknown
22
39%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 October 2016.
All research outputs
#14,268,952
of 22,881,964 outputs
Outputs from Diabetes
#7,234
of 9,214 outputs
Outputs of similar age
#214,791
of 365,664 outputs
Outputs of similar age from Diabetes
#94
of 112 outputs
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