most study agree on generic been the main factor and dietary intake in the end of the list https://t.co/Mt34XrEbxn Ordered List of Factors 1. Genetics 2. Saturated and Unsaturated Fat Intake 3. Lifestyle Factors (Obesity, Physical Inactivity, Smoking…
All those years working out the genetic architecture of high TG (L) yielding 🍎🍐🍊 😊 Supplementary Figure 3 from Teslovich, @kiranmusunuru, Nature 2010 (R): very high TG, much of it is polygenic in origin https://t.co/VXxv4dVcs3 https://t.co/DmqTH5W…
@jasonssimon @dgmacarthur Also I have to point out your study is a candidate gene study with p-values of 0.0043. https://t.co/y92I6NKLJf The earliest GWS signal I can find at NPC1L1 is from the 95 lipid loci paper: https://t.co/zt71XK0D3p
@drpablocorral @mbelshazly @RensReeskamp @amitvkhera Humphries 12-SNP score would be even worse than the 28-SNP one used in the current study. We initially described by the 12-SNP LDL-C score in below paper and showed enrichment in high LDL-C patients…