An elevated fibroblast growth factor (FGF) 23 is an independent risk factor for cardiovascular disease and mortality in patients with kidney disease. The relationship between FGF23 and cause-specific mortality in the general population is unknown.
To investigate the association of elevated FGF23 with risk of cause-specific mortality in a racially and ethnically diverse urban general population.
The Northern Manhattan Study is a population-based prospective cohort study. Residents who were >39 years old, with no history of stroke were enrolled between 1993 and 2001. Participants with available blood samples for baseline FGF23 testing were included in the current study (n=2525).
Cause-specific death events.
A total of 1198 deaths (474 vascular, 612 non-vascular, 112 unknown cause) occurred during a median follow-up of 14 years. Compared to participants in the lowest FGF23 quintile, those in the highest quintile had a 2.07-fold higher risk (95% confidence interval [CI] 1.45, 2.94) of vascular death and a 1.64-fold higher risk (95% CI 1.22, 2.20) of non-vascular death in fully adjusted models. Higher FGF23 was independently associated with increased risk of mortality due to cancer, but only in Hispanic participants (hazard ratio per 1 unit increase in ln FGF23 of 1.87; 95% CI 1.40, 2.50; P for interaction = 0.01).
Elevated FGF23 was independently associated with increased risk of vascular and non-vascular mortality in a diverse general population, and with increased risk of cancer death specifically in Hispanic individuals.
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 August 2016.
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