Probenecid effects on cephalexin pharmacokinetics and pharmacodynamics in healthy volunteers

Overview of attention for article published in Journal of Infection, June 2021

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RP @steventong.bsky.social: Typically using it with cefalexin 1g q6h plus probenecid 500mg q6h (or q12h if elderly / some renal impairment). See pubmed.ncbi.nlm.nih.gov/34081957/. Healthy volunteers. But colleagues have used these regimens and done lev…

Very Interesting concept, thank you https://bsky.app/profile/did:plc:klwvdtksagcziyylwqukjgal/post/3lb2kom77oc2h

Richard Everts from NZ has some nice studies: Cefalexin: pubmed.ncbi.nlm.nih.gov/34081957/. Flucloxacillin: pubmed.ncbi.nlm.nih.gov/33963595/ and pubmed.ncbi.nlm.nih.gov/31521742/ Some supportive clinical data: pubmed.ncbi.nlm.nih.gov/32015029/ Based …

Typically using it with cefalexin 1g q6h plus probenecid 500mg q6h (or q12h if elderly / some renal impairment). See pubmed.ncbi.nlm.nih.gov/34081957/. Healthy volunteers. But colleagues have used these regimens and done levels in patients which are co…

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