Growing evidence shows that regulatory variation in enhancers is often shared across tissues (https://t.co/i0kx11O37O ) and that it can contribute to common disease risk (https://t.co/ZdzqHwFxrN). Here, we show that tissue-shared enhancers may contribut…
Example: Multiple variants control the expression of IRX3 and IRX5 genes in both adipose tissue and brain, the coordinated effects of which (less thermogenesis and more feeding behavior) result in obesity. https://t.co/zqVEFZCOdV
@markmccarthyoxf @JimJohnsonSci @GilesYeo @JohnSpeakman4 @garytaubes Adding to this, Marcelo’s group recently showed that the target genes' effects(IRX3/5) on both adipose tissue and brain cells, and they play a role in regulating dietary preferences. htt…