Chronic electronic cigarette exposure in mice induces features of COPD in a nicotine-dependent manner

Overview of attention for article published in Thorax, August 2016

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In the top 5% of all research outputs scored by Altmetric
Among the highest-scoring outputs from this source (#45 of 7,506)
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This paper has 4 comments on PubPeer, an open scientific commentary website.

Comment from PubMed Commons

31 Aug 2016

Peter Hajek | Aug 30 2016 17:30 ESTThe length of exposure would be relevant if the dosing was comparable, but the damage to mice lungs was caused by doses of nicotine that were many times above…

Comment from PubMed Commons

30 Aug 2016

Robert Foronjy | Aug 30 2016 07:39 ESTThe study is NOT reassuring to e-cigarette consumers. On the contrary, it shows that nicotine exposure reproduced the lung structural and physiologic changes…

Comment from PubMed Commons

29 Aug 2016

Peter Hajek | Aug 29 2016 13:38 ESTThank you for the explanation. The exposure however was not equivalent. Mice have much faster nicotine metabolism than humans which means that nicotine exposure in…

Robert Foronjy | Aug 29 2016 11:58 ESTMortality was not reported in the manuscript since no deaths occurred. The exposure was well tolerated by the mice and no abnormal behavior or physiologic stress…

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