Structure-Guided Design of Conformationally Constrained Cyclohexane Inhibitors of Severe Acute Respiratory Syndrome Coronavirus‑2 3CL Protease

Overview of attention for article published in Journal of Medicinal Chemistry, July 2021

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Good work: Structure-Guided Design of Conformationally Constrained Cyclohexane Inhibitors of Severe Acute Respiratory Syndrome Coronavirus-2 3CL Protease https://t.co/QklWyqr9JA

I know we've lowered standards for COVID related work, but... As far as I can tell, this paper takes an existing inhibitor with a cyclohexane in it and attempts to "conformationally constrain" it. One constrained moiety maintains potency, thus paper? h…

Structure-Guided Design of Conformationally Constrained Cyclohexane Inhibitors of Severe Acute Respiratory Syndrome Coronavirus-2 3CL Protease https://t.co/sGz39J6ADm

New article: Structure-Guided Design of Conformationally Constrained Cyclohexane Inhibitors of Severe Acute Respiratory Syndrome Coronavirus-2 3CL Protease https://t.co/v3oHlnhF0E #coronavirus #COVID19 #2019ncov https://t.co/N5Mkg7HEe7

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