Site interdependence attributed to tertiary structure in amino acid sequence evolution

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RT @ematsen: Has anyone built a phylogenetic inference tool yet where ancestral sequences are constrained to fold well according to AlphaFo…

Has anyone built a phylogenetic inference tool yet where ancestral sequences are constrained to fold well according to AlphaFold2? The closest thing I can think of is the work by Rodrigue et al in the mid 2000s: https://t.co/CcpG6T2zjw

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