Compounds targeting OSBPL7 increase ABCA1-dependent cholesterol efflux preserving kidney function in two models of kidney disease

Overview of attention for article published in Nature Communications, August 2021

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RT @rheault_m: Compounds targeting OSBPL7 increase ABCA1-dependent cholesterol efflux preserving kidney function in two models of kidney di…

Compounds targeting OSBPL7 increase ABCA1-dependent cholesterol efflux preserving kidney function in two models of kidney disease (including #Alport syndrome) https://t.co/0iPVfEqHFx https://t.co/iEba8szYlN

The @MiamiAlessia & Prunotto (@Roche) teams show that a new lead series of 5-arylnicotinamide drugs restore function in disease models (kidney & ?others). The drugs bind to OSBPL7's sterol transfer domain and stimulate cholesterol efflux to HDL.…

RT @KSusztak: ⁦@MiamiAlessia⁩ and team Compounds targeting OSBPL7 increase ABCA1-dependent cholesterol efflux preserving kidney function in…

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