Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths

Overview of attention for article published in Science Immunology, August 2021

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7/ Since then, our studies have consistently identified the same mechanism in various viruses. Approximately 20% of COVID-19 deaths are attributed to antibodies that are already present in about 4% of individuals over the age of 70. https://t.co/ep78vsSo3W

6/ In 2021, we reported that 15% and 20% of patients with life-threatening and lethal COVID-19, respectively, carried auto-Abs neutralizing physiological concentrations of type I IFNs (https://t.co/ePZ66VQWyU).

13/ Auto-antibodies neutralizing type I IFNs were shown to be pathogenic from 2020 onward, accounting for 15% of cases of life-threatening COVID-19: https://t.co/oTa8OC7YUR and https://t.co/ep78vsSo3W

3/ In 2021 we showed that the proportion increased to 15% when considering auto-Abs neutralizing lower, more physiological concentrations of type I IFNs. https://t.co/CdvbC0PZQd

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