🧪 A team led by Drs. Leonard Petrucelli and Mercedes Prudencio at @MayoClinicNeuro found that PGRN loss affects #microglial activation and #lysosomal function, resulting in the accumulation of myelin debris and contributing to TDP-43 pathology. https://t…
RT @CellReports: Microglial lysosome dysfunction contributes to white matter pathology and TDP-43 proteinopathy in GRN-associated FTD https…
RT @CellReports: Microglial lysosome dysfunction contributes to white matter pathology and TDP-43 proteinopathy in GRN-associated FTD https…
RT @CellReports: Microglial lysosome dysfunction contributes to white matter pathology and TDP-43 proteinopathy in GRN-associated FTD https…