@jogleeson_ucsd One of the 2012 papers from my lab showed that 1) 1-2 new mutations per year accumulate in sperm AND 2) AUTISM genes have higher intrinsic mutability than other genes. Consequently mutations are more concentrated in genes involved in ASD…
@JillEscher Yes Aaron's paper is really cool See also these papers from us and decode in 2012 https://t.co/XUAj99vLSD https://t.co/gsfZ72nI22
@JoramKeijser @WesleyPClawson @RobertTLange @imartincorena This may be of interest. Mutation rates in human don’t appear to be reduced in highly conserved DNA, to the contrary
@Graham_Coop Graham this is fascinating! Congrats on the paper. Some results results from analysis of DNMs in humans contrasts somewhat with what you are seeing in plants. I wonder if there are real differences or if other technical factors may explain …