A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response

Overview of attention for article published in Nature Genetics, October 2021

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twitter: 77 X users
patent: 3 patents

q&a: 1 Q&A thread

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Valine encoding HLA-DRB1 alleles are one of the strongest genetic risk factors for RA risk and severity https://t.co/CzbW96WHLR, so we leveraged WGS-extracted alleles in #TOPMed by @soumya_boston lab 👇 https://t.co/Rtx99nBHup

Good news for HLA imputation 😊- using our previously constructed multi-ancestry HLA reference panel (https://t.co/Qc7yCF1Fii), common #HLA alleles (>1%) showed high performance among African individuals.

A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response https://t.co/TgG0AVXq29 #science #genomics

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