Obesity has been correlated with high grades of prostate cancer. Body mass index and waist circumference are not good surrogates for obesity.
To evaluate whether periprostatic fat volume and periprostatic fat ratio as determined by multi-parametric magnetic resonance imaging correlates with the presence of high-grade prostate cancer.
A total of 295 consecutive patients (Median age 64, range 38-84) underwent mpMRI of the prostate gland between August 2013 and February 2015. All patients underwent a 3 Tesla multi-parametric MRI. Using DynaCAD (Invivo, Gainesville Florida, USA), we calculated the prostate volume and volume of the periprostatic fat seen on mpMRI. The peri-prostatic fat ratio was calculated using the formula peri-prostatic fat volume / prostate volume).
A higher periprostatic fat volume (p<0.001) and a higher periprostatic fat ratio (p<0.001) were significantly associated with a higher Gleason Score. Periprostatic fat ratio is a better predictor of higher Gleason Score compare to periprostatic fat volume (p<0.001). There was no correlation observed between periprostatic fat ratio and PSA (Median 7.34, range 0.36-59.7, p=0.274), age (Median 64, range 38-84, p=0.665) or BMI (Median 28.33, range 17.99-45.44, p=0.310). Patients with a higher periprostatic fat ratio were more likely to undergo intervention for prostate cancer.
A higher periprostatic fat ratio is significantly associated with a higher Gleason Score. Periprostatic fat ratio is a better predictor of higher Gleason Score compare to periprostatic fat volume and may be an important risk factor in diagnosing patients higher grade prostate cancer.
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 September 2016.
All research outputs
#5,156,627
of 25,374,647 outputs
Outputs from Urology
#1,534
of 7,811 outputs
Outputs of similar age
#81,481
of 348,376 outputs
Outputs of similar age from Urology
#28
of 188 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,811 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 348,376 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 188 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.
