Adhesion GPCR Latrophilin 3 regulates synaptic function of cone photoreceptors in a trans-synaptic manner

Overview of attention for article published in Proceedings of the National Academy of Sciences of the United States of America, November 2021

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Splice isoform of LPHN3 excludes a element with inhibitory influence on transsynaptic interactions. Gain-of-function mouse model specifically routing LPHN3 splicing to this isoform diminished CaV1.4 calcium channel activity profoundly disrupted synaptic…

And here's another recent paper investigating the role of #adhesion #GPCRs in the CNS🧠: Latrophilin 3/ADGRL3 regulates synaptic function of cone photoreceptors in a trans-synaptic manner! https://t.co/nk1KTKgyUv #AdhernRise #ca18240

RT @KLabGPCR: Lab's first foray into fascinating world of adhesion #GPCR. We find novel inhibitory element in the ectodomain regulated by s…

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