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RT @Biochem_Journal: New #OpenAccess research showing that the binding of mycolactone to Sec61α is reminiscent of the ‘foot-in-the-door' me…
RT @Biochem_Journal: New #OpenAccess research showing that the binding of mycolactone to Sec61α is reminiscent of the ‘foot-in-the-door' me…
New #OpenAccess research showing that the binding of mycolactone to Sec61α is reminiscent of the ‘foot-in-the-door' mechanism suggested earlier for cotransin and eeyarestatin compounds https://t.co/s5b9AhVUjV https://t.co/PpdnGc4k2z
Mycolactone traps Sec61 translocons in a Ca2+ permeable state: Ca2+ leak from the ER can be seen within 20 mins, likely a critical factor in the cellular responses observed in #buruliulcer. https://t.co/7NI2esWrqd