Outcomes of retransplantation after initial living donor liver transplantation (LDLT) are poorly understood. The aim of this study is to better understand the indications, timing and outcomes of retransplantation after initial LDLT when compared to after initial deceased donor transplantation (DDLT). From 2002-2013, 209 retransplant recipients after initial LDLT and 2,893 after initial DDLT were identified in OPTN/UNOS. Multivariable logistic models evaluated the association between initial transplant type and 1-year mortality. The most frequent reason for early graft failure (≤14 days) in LDLT recipients was vascular thrombosis (63.6%) vs primary graft failure in initial DDLT recipients (59.1%). LDLT recipients were more often acutely and/or critically ill with a greater proportion of Status 1 (42.6% vs 27.3%; p<0.001) and intensive care unit (52.2% vs 39.9%; p=0.001) recipients at the time of retransplantation. There was no difference in adjusted 1-year mortality between retransplant recipients after initial LDLT vs DDLT (OR 0.74; 95% CI 0.51-1.08). The proportion of recipients who ultimately required retransplantation for a third time was not different between the two groups (4.8%). Retransplantation outcomes after LDLT are not different than other retransplant procedures, despite recipients having greater acuity of illness and different indications. This article is protected by copyright. All rights reserved.