Ionizing radiation is a well-established carcinogen in rodent models and a risk factor associated with human cancer. We developed a mouse model that captures radiation effects on host biology by transplanting unirradiated Trp53-null mammary tissue to sham or irradiated hosts. Gene expression profiles of tumors that arose in irradiated mice are distinct from those that arose in naïve hosts. We asked whether expression metaprofiles could discern radiation-preceded human cancer or be informative in sporadic breast cancers.
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 February 2013.
All research outputs
#20,178,948
of 22,693,205 outputs
Outputs from Clinical Cancer Research
#11,877
of 12,573 outputs
Outputs of similar age
#171,807
of 196,095 outputs
Outputs of similar age from Clinical Cancer Research
#139
of 181 outputs
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