| Title |
A Tol2 Gateway-Compatible Toolbox for the Study of the Nervous System and Neurodegenerative Disease
|
|---|---|
| Published in |
Zebrafish, September 2016
|
| DOI | 10.1089/zeb.2016.1321 |
| Pubmed ID | |
| Authors | |
| Abstract |
Currently there is a lack in fundamental understanding of disease progression of most neurodegenerative diseases, and, therefore, treatments and preventative measures are limited. Consequently, there is a great need for adaptable, yet robust model systems to both investigate elementary disease mechanisms and discover effective therapeutics. We have generated a Tol2 Gateway-compatible toolbox to study neurodegenerative disorders in zebrafish, which includes promoters for astrocytes, microglia and motor neurons, multiple fluorophores, and compatibility for the introduction of genes of interest or disease-linked genes. This toolbox will advance the rapid and flexible generation of zebrafish models to discover the biology of the nervous system and the disease processes that lead to neurodegeneration. |
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X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 4 | 36% |
| United States | 3 | 27% |
| Unknown | 4 | 36% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 9 | 82% |
| Scientists | 2 | 18% |
Mendeley demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 103 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 22 | 21% |
| Student > Ph. D. Student | 18 | 17% |
| Professor > Associate Professor | 10 | 10% |
| Student > Master | 9 | 9% |
| Student > Doctoral Student | 6 | 6% |
| Other | 17 | 17% |
| Unknown | 21 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 27 | 26% |
| Neuroscience | 22 | 21% |
| Agricultural and Biological Sciences | 18 | 17% |
| Medicine and Dentistry | 5 | 5% |
| Environmental Science | 2 | 2% |
| Other | 4 | 4% |
| Unknown | 25 | 24% |