Noradrenaline can modulate multiple cellular functions important for cancer progression; however, how this single extracellular signal regulates such a broad array of cellular processes is unknown. Here we identify Src as a key regulator of phosphoproteomic signalling networks activated in response to beta-adrenergic signalling in cancer cells. These results also identify a new mechanism of Src phosphorylation that mediates beta-adrenergic/PKA regulation of downstream networks, thereby enhancing tumour cell migration, invasion and growth. In human ovarian cancer samples, high tumoural noradrenaline levels were correlated with high pSrc(Y419) levels. Moreover, among cancer patients, the use of beta blockers was significantly associated with reduced cancer-related mortality. Collectively, these data provide a pivotal molecular target for disrupting neural signalling in the tumour microenvironment.
This research output has an Altmetric Attention Score of 26. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 May 2022.
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#1,783,889
of 32,473,710 outputs
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#26,601
of 78,081 outputs
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#14,335
of 332,322 outputs
Outputs of similar age from Nature Communications
#46
of 267 outputs
Altmetric has tracked 32,473,710 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 78,081 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 50.1. This one has gotten more attention than average, scoring higher than 65% of its peers.
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We're also able to compare this research output to 267 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.
