Unbiased screen identifies aripiprazole as a modulator of abundance of the polyglutamine disease protein, ataxin-3

Overview of attention for article published in Brain, September 2016

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Aripiprazole increased longevity in a fly model of Machado-Joseph, a polyglutamine (polyQ) disease, and reduced aggregated ATXN3 species in flies and in brains of transgenic mice treated for 10 days. Could NRF2 activation explain its rescue effects? htt…

RT @ibrahimimam2000: Aripiprazole promising in spinocerebellar ataxia type 3 (SCA 3, Machado Joseph disease) https://t.co/RzltO8zHKV

Aripiprazole promising in spinocerebellar ataxia type 3 (SCA 3, Machado Joseph disease) https://t.co/RzltO8zHKV

RT @neurochecklists: Aripiprazole as a potential treatment for SCA3 via @Brain1878 https://t.co/qokWmweiuQ https://t.co/NdBgyPa4zX

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