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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Dietary Lactobacillus-Derived Exopolysaccharide Enhances Immune-Checkpoint Blockade TherapyDietary Exopolysaccharide Enhances ICB Therapy Efficacy
|
|---|---|
| Published in |
Cancer Discovery, February 2022
|
| DOI | 10.1158/2159-8290.cd-21-0929 |
| Pubmed ID | |
| Authors |
Hirotaka Kawanabe-Matsuda, Kazuyoshi Takeda, Marie Nakamura, Seiya Makino, Takahiro Karasaki, Kazuhiro Kakimi, Megumi Nishimukai, Tatsukuni Ohno, Jumpei Omi, Kuniyuki Kano, Akiharu Uwamizu, Hideo Yagita, Ivo Gomperts Boneca, Gérard Eberl, Junken Aoki, Mark J. Smyth, Ko Okumura |
| Abstract |
Microbes and their byproducts have been reported to regulate host health and immune functions. Here we demonstrated that microbial exopolysaccharide produced by Lactobacillus delbrueckii subsp. bulgaricus OLL1073R-1 (EPS-R1) induced CCR6+ CD8+ T cells of mice and humans. In mice, ingestion of EPS-R1 augmented anti-tumor effects of anti-CTLA-4 or anti-PD-1 mAb against CCL20-expressing tumors, in which infiltrating CCR6+ CD8+ T cells were increased and produced IFN-gamma accompanied by a substantial immune response gene expression signature maintaining T cell functions. Of note, the anti-tumor adjuvant effect of EPS-R1 was also observed in germ-free mice. Furthermore, the induction of CCR6 expression was mediated through the phosphorylated structure in EPS-R1 and a lysophosphatidic acid (LPA) receptor on CD8+ T cells. Overall, we find that dietary EPS-R1 consumption induces CCR6+ CD8+ T cells in Peyer's patches, favoring a tumor microenvironment that augments the therapeutic effect of immune checkpoint blockade depending on CCL20 production by tumors. |
X Demographics
The data shown below were collected from the profiles of 22 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 7 | 32% |
| United Kingdom | 2 | 9% |
| Japan | 2 | 9% |
| Brazil | 1 | 5% |
| Canada | 1 | 5% |
| Unknown | 9 | 41% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 15 | 68% |
| Science communicators (journalists, bloggers, editors) | 4 | 18% |
| Scientists | 2 | 9% |
| Practitioners (doctors, other healthcare professionals) | 1 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 42 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 19% |
| Researcher | 3 | 7% |
| Student > Doctoral Student | 3 | 7% |
| Student > Bachelor | 2 | 5% |
| Student > Postgraduate | 2 | 5% |
| Other | 5 | 12% |
| Unknown | 19 | 45% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 7 | 17% |
| Immunology and Microbiology | 4 | 10% |
| Medicine and Dentistry | 3 | 7% |
| Agricultural and Biological Sciences | 2 | 5% |
| Unspecified | 1 | 2% |
| Other | 2 | 5% |
| Unknown | 23 | 55% |
Attention Score in Context
This research output has an Altmetric Attention Score of 30. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 March 2023.
All research outputs
#1,238,286
of 24,417,958 outputs
Outputs from Cancer Discovery
#620
of 3,893 outputs
Outputs of similar age
#30,358
of 431,859 outputs
Outputs of similar age from Cancer Discovery
#38
of 144 outputs
Altmetric has tracked 24,417,958 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,893 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 21.0. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 431,859 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 144 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.