Over the last years, physiological studies have proved that ventilation with a oxygenated liquid perfluorocarbon (PFC) provides effective gas exchange and acid base balance and improves lung function and recovery. Low surface tension and high respiratory gas solubility enable adequate oxygenation and carbon dioxide removal at low insufflation pressure. The elimination of air-liquid interfacial surface tension has recently suggested the adoption of total liquid PFC ventilation as an investigational therapy for severe respiratory distress in human infants. This work is aimed to determine the optimal volumes of PFC to be delivered, the frequency of the ventilatory cycle, the oxygen flow rate and the best circuit set up for neonatal application. The optimisation was obtained through the implementation of a simulation mathematical model of oxygen diffusion in a PFC-ventilated lung and of gas exchange between alveolar environment and pulmonary blood flow. The results show that total liquid ventilation is a valid alternative to traditional gas ventilation, particularly when immature neonates with insufficient or absent production of surfactant are concerned.
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 August 2026.
All research outputs
#10,032,900
of 34,156,109 outputs
Outputs from The International Journal of Artificial Organs
#276
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Outputs of similar age
#15,245
of 39,377 outputs
Outputs of similar age from The International Journal of Artificial Organs
#3
of 8 outputs
Altmetric has tracked 34,156,109 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 1,055 research outputs from this source. They receive a mean Attention Score of 4.8. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 39,377 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.
