Abdominal pain, emergency department visits and hospitalizations impact lives of children with acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP). However, data on health-related quality of life (HRQOL) in this population remains limited. We aimed to evaluate HRQOL in children with ARP or CP; and test biopsychosocial risk factors associated with low HRQOL.
Data were acquired from the INternational Study Group of Pediatric Pancreatitis: In search for a cuRE registry. Baseline demographic and clinical questionnaires, the Child Health Questionnaire (measures HRQOL) and Child Behavior Checklist (measures emotional and behavioral functioning) were completed at enrollment.
The sample included 368 children (54.3% females, mean age = 12.7 years, SD = 3.3); 65.2% had ARP and 34.8% with CP. Low physical HRQOL (M = 38.5, SD = 16.0) was demonstrated while psychosocial HRQOL (M = 49.5, SD = 10.2) was in the normative range. Multivariate regression analysis revealed that clinical levels of emotional and behavioral problems (B = -10.28, p < .001), episodic and constant abdominal pain (B = -4.66, p = .03; B = -13.25, p < .001) were associated with low physical HRQOL, after accounting for ARP/CP status, age, sex, exocrine and endocrine disease (F (9, 271) = 8.34, p < .001). Borderline and clinical levels of emotional and behavioral problems (B = -10.18, p < .001; B = -15.98, p < .001), and constant pain (B = -4.46, p < .001) were associated with low psychosocial HRQOL (F (9, 271) = 17.18, p < .001).
Findings highlight the importance of assessing HRQOL and treating pain and psychosocial problems in this vulnerable group of children.
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This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 June 2022.
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