Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data

Overview of attention for article published in Nature Genetics, March 2022

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Good point - it is possible - yet I think LDSC being significant also suggests that it is not a majority and the PRS developed worked well. This TOPMED paper is an interesting exploration of these issues. pmc.ncbi.nlm.nih.gov/articles/PMC...

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