Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data

Overview of attention for article published in Nature Genetics, March 2022

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So far, Altmetric has seen 8 Reddit threads by 7 users.

Iirc, you can recover a lot of heritability if you sequence...

User muchmoreforsure, in the Genetics, genes, and genomes subreddit, 09 Feb 2025

Iirc, you can recover a lot of heritability if you sequence the entire genome to look at rare variants (which GWAS misses). The…

I haven't read most of the threads, but both "sides" seem...

User kaneliomena, in the Blocked and Reported subreddit, 30 Jan 2024

I haven't read most of the threads, but both "sides" seem to be getting ahead of the data at times. For example, Gusev is right…

>You can't account for rare variation with these models if...

User DefenestrateFriends, in the Genetics, genes, and genomes subreddit, 27 Apr 2023

>You can't account for rare variation with these models if you don't actually measure, which in many of the studies we're…

This is getting a bit laborious, and we clearly have...

User Holodoxa, in the Genetics, genes, and genomes subreddit, 27 Apr 2023

This is getting a bit laborious, and we clearly have different positions, but i'll respond to some things while I have time. …

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