Boc3Arg-Linked Ligands Induce Degradation by Localizing Target Proteins to the 20S Proteasome

Overview of attention for article published in ACS Chemical Biology, October 2016

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待ってアルギニン側鎖の窒素って全部保護できるの？共鳴しているところ、反応性低くない？ https://t.co/V2CvjZ7pha

マジ？ https://t.co/KCuuow3AiI

RT @onaka_empty: あと個人的に、Arginineの３つの窒素をBocで保護した単純な構造がプロテアソームに認識されるらしく、これを利用したたんぱく質分解誘導薬も結構面白いなと思っている。活性はPROTACsには及ばないけど、研究人口が増えたらいい技術になりそう。…

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