SignificanceNeedleless delivery into the skin would overcome a major barrier to efficient clinical utilization of advanced therapies such as nanomaterials and macromolecules. This study demonstrates that controlled skin stretching (in porcine, rat, and mouse models) using a patch comprising a hypobaric chamber, to open the skin appendages, can increase the permeability of the tissue and provide a means to enable direct delivery of advanced therapies directly into the skin without the use of a needle or injection system. This technology can facilitate the self-administration of therapeutics including vaccines, RNA, and antigens, thus improving the translation of these products into effective clinical use.
Pharmacology, Toxicology and Pharmaceutical Science
4
11%
Medicine and Dentistry
3
8%
Engineering
3
8%
Biochemistry, Genetics and Molecular Biology
1
3%
Business, Management and Accounting
1
3%
Other
0
0%
Unknown
24
67%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 April 2022.
All research outputs
#24,773,717
of 34,383,983 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#109,068
of 118,948 outputs
Outputs of similar age
#297,210
of 470,673 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#715
of 797 outputs
Altmetric has tracked 34,383,983 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 118,948 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 40.1. This one is in the 4th percentile – i.e., 4% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 470,673 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 797 others from the same source and published within six weeks on either side of this one. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.
