Disrupting autorepression circuitry generates “open-loop lethality” to yield escape-resistant antiviral agents

Thank you for tweeting about the talk! Just a minor correction, it’s IE2 negative circuit and not the IE1 positive circuit we are targeting. Happy to discuss the work during break!

RT @CicinSain_Lab: S. Chaturvedi gave a talk at #IHW2023 on their #Cell paper: https://t.co/jQOYXJWMah She argues that a 28 nucleotide dsD…

S. Chaturvedi gave a talk at #IHW2023 on their #Cell paper: https://t.co/jQOYXJWMah She argues that a 28 nucleotide dsDNA acting as a sinkhole for IE1 prevents a self-regulatory loop, enhances IE1 gene expression and drives apoptosis, proposing to use …

Here is a link to the manuscript on feedback disruptors as escape-resistant strategy that came out in @CellPressNews this month! https://t.co/izdDQiz1Sz