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Mendeley demographics
| Title |
A Small-Molecule Inhibitor of Iron-Sulfur Cluster Assembly Uncovers a Link between Virulence Regulation and Metabolism in Staphylococcus aureus
|
|---|---|
| Published in |
Cell Chemical Biology, October 2016
|
| DOI | 10.1016/j.chembiol.2016.09.012 |
| Pubmed ID | |
| Authors | |
| Abstract |
The rising problem of antimicrobial resistance in Staphylococcus aureus necessitates the discovery of novel therapeutic targets for small-molecule intervention. A major obstacle of drug discovery is identifying the target of molecules selected from high-throughput phenotypic assays. Here, we show that the toxicity of a small molecule termed '882 is dependent on the constitutive activity of the S. aureus virulence regulator SaeRS, uncovering a link between virulence factor production and energy generation. A series of genetic, physiological, and biochemical analyses reveal that '882 inhibits iron-sulfur (Fe-S) cluster assembly most likely through inhibition of the Suf complex, which synthesizes Fe-S clusters. In support of this, '882 supplementation results in decreased activity of the Fe-S cluster-dependent enzyme aconitase. Further information regarding the effects of '882 has deepened our understanding of virulence regulation and demonstrates the potential for small-molecule modulation of Fe-S cluster assembly in S. aureus and other pathogens. |
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X Demographics
The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 7 | 64% |
| Singapore | 1 | 9% |
| United Kingdom | 1 | 9% |
| Bolivia, Plurinational State of | 1 | 9% |
| Peru | 1 | 9% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 6 | 55% |
| Members of the public | 3 | 27% |
| Science communicators (journalists, bloggers, editors) | 2 | 18% |
Mendeley demographics
The data shown below were compiled from readership statistics for 97 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 97 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 16% |
| Researcher | 11 | 11% |
| Student > Doctoral Student | 9 | 9% |
| Student > Bachelor | 7 | 7% |
| Student > Master | 7 | 7% |
| Other | 15 | 15% |
| Unknown | 32 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 22 | 23% |
| Agricultural and Biological Sciences | 11 | 11% |
| Immunology and Microbiology | 11 | 11% |
| Chemistry | 6 | 6% |
| Medicine and Dentistry | 4 | 4% |
| Other | 8 | 8% |
| Unknown | 35 | 36% |