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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Stress Granules Determine the Development of Obesity-Associated Pancreatic Cancer.
|
|---|---|
| Published in |
Cancer Discovery, June 2022
|
| DOI | 10.1158/2159-8290.cd-21-1672 |
| Pubmed ID | |
| Authors |
Guillaume Fonteneau, Alexandra Redding, Hannah Hoag-Lee, Edward S Sim, Stefan Heinrich, Matthias M Gaida, Elda Grabocka |
| Abstract |
Obesity is a global epidemic and a major predisposing factor for cancer. Increasing evidence shows that obesity-associated stress is a key driver of cancer risk and progression. Previous work has identified the phase-separation organelles, stress granules (SGs), as mutant KRAS-dependent mediators of stress adaptation. However, the dependence of tumorigenesis on these organelles is unknown. Here, we establish a causal link between SGs and pancreatic ductal adenocarcinoma (PDAC). Importantly, we uncover that dependence on SGs is drastically heightened in obesity-associated PDAC. Furthermore, we identify a previously unknown regulator and component of SGs, namely the serine/arginine protein kinase 2 (SRPK2), as a specific determinant of SG formation in obesity-associated PDAC. We show that SRPK2-mediated SG formation in obesity-associated PDAC is driven by hyperactivation of the IGF1/PI3K/mTOR/S6K1 pathway, and that S6K1 inhibition selectively attenuates SGs and impairs obesity-associated PDAC development. |
X Demographics
The data shown below were collected from the profiles of 83 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 41 | 49% |
| United Kingdom | 2 | 2% |
| India | 2 | 2% |
| Tanzania, United Republic of | 1 | 1% |
| Austria | 1 | 1% |
| Paraguay | 1 | 1% |
| France | 1 | 1% |
| Australia | 1 | 1% |
| Italy | 1 | 1% |
| Other | 1 | 1% |
| Unknown | 31 | 37% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 39 | 47% |
| Scientists | 31 | 37% |
| Practitioners (doctors, other healthcare professionals) | 8 | 10% |
| Science communicators (journalists, bloggers, editors) | 5 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 24 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 3 | 13% |
| Researcher | 3 | 13% |
| Unspecified | 1 | 4% |
| Professor | 1 | 4% |
| Student > Doctoral Student | 1 | 4% |
| Other | 2 | 8% |
| Unknown | 13 | 54% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 5 | 21% |
| Medicine and Dentistry | 4 | 17% |
| Unspecified | 1 | 4% |
| Economics, Econometrics and Finance | 1 | 4% |
| Agricultural and Biological Sciences | 1 | 4% |
| Other | 0 | 0% |
| Unknown | 12 | 50% |
Attention Score in Context
This research output has an Altmetric Attention Score of 175. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 October 2023.
All research outputs
#232,979
of 25,559,053 outputs
Outputs from Cancer Discovery
#84
of 4,079 outputs
Outputs of similar age
#6,745
of 449,220 outputs
Outputs of similar age from Cancer Discovery
#6
of 120 outputs
Altmetric has tracked 25,559,053 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,079 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 21.6. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 449,220 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 120 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.