Alzheimer's disease (AD) is a progressive neurodegenerative disease affecting cognitive and functional abilities. However, many patients presume lower cognitive or functional abilities because of aging and do not undergo clinical assessments until the symptoms become too advanced. Developing a low-cost and easy-to-use AD detection tool, which can be used in any clinical or non-clinical setting, can enable widespread AD assessments and diagnosis. This paper investigated the feasibility of developing such a tool to detect AD vs. healthy control (HC) from a simple balance and walking assessment called the Timed Up and Go (TUG) test. We collected joint position data of 47 HC and 38 AD subjects as they performed TUG in front of a Kinect V.2 camera. Our signal processing and statistical analyses provided a comprehensive analysis of balance and gait with 12 significant features for discriminating AD from HC after adjusting for age and the Geriatric Depression Scale. Using these features and a support vector machine classifier, our model classified the two groups with an average accuracy of 97.75% and an F-score of 97.67% for five-fold cross-validation and 98.68% and 98.67% for leave-one-subject out cross-validation. These results demonstrate the potential of our approach as a new quantitative complementary tool for detecting AD among older adults. Our work is novel as it presents the first application of Kinect V.2 camera and machine learning to provide a comprehensive and quantitative analysis of the TUG test to detect AD patients from HC. This study supports the feasibility of developing a low-cost and convenient AD assessment tool that can be used during routine checkups or even at home; however, future investigations could confirm its clinical diagnostic value in a larger cohort.
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 June 2022.
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Outputs from IEEE Transactions on Neural Systems and Rehabilitation Engineering
#121
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#81,506
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Outputs of similar age from IEEE Transactions on Neural Systems and Rehabilitation Engineering
#1
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Altmetric has tracked 27,273,687 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,513 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 450,622 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.
