Trial of Amitriptyline, Topiramate, and Placebo for Pediatric Migraine

Overview of attention for article published in New England Journal of Medicine, October 2016

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In the top 5% of all research outputs scored by Altmetric
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news: 130 news outlets
blogs: 7 blogs
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mendeley: 425 Mendeley

So far, Altmetric has seen 8 Reddit threads by 7 users.

Is Amitriptyline BS? Confused about conflicting studies.

User Informal-Elevator-41, in the Migraine subreddit, 08 Dec 2025

Placebo effect, at least in pediatrics. See CHAMP trial....

User akakgo, in the It's all about the Brain! subreddit, 30 Nov 2023

Placebo effect, at least in pediatrics. See CHAMP trial. https://www.nejm.org/doi/full/10.1056/nejmoa1610384

>Actually, the placebo effect works even in people who...

User a_neurologist, in the /r/medicine: a subreddit for medical professionals subreddit, 12 Feb 2022

>Actually, the placebo effect works even in people who are told they are about to take a placebo.  It can, but not as…

I administer Botox for migraine (it's my fifth line, after...

User tirral, in the /r/medicine: a subreddit for medical professionals subreddit, 11 Feb 2022

I administer Botox for migraine (it's my fifth line, after patient fails 3 oral prophylactics and 2 CGRPs). As much as I hate…

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