To evaluate the short and long-term surgical outcomes after urinary diversion (UD) done for urinary adverse events (UAEs) arising from prostate radiation therapy (RT). We hypothesized patient characteristics are associated with complications after UD.
A retrospective cohort study of 100 men who underwent UD (urinary conduit or continent catheterizable pouch) due to UAEs following prostate RT from 2007-2016 from nine academic centers in the United States. Outcome measurements included predictors of short and long-term complications, and readmission after UD in post-RT prostate cancer patients. The data was summarized using descriptive statistics and univariate associations with complications were identified with logistic regression controlling for center.
Mean age was 71 years and median time from RT to UD was 8 years. Eighty-one (81%) patients had combined-modality therapy (radical prostatectomy plus RT or various combinations of RT). Grade 3a or greater Clavien-Dindo complications occurred in 31 (35%) men including 4 deaths (4.5%). Normal weight men had higher short-term complications compared to overweight (odds ratio (OR)= 4.9, 95% CI: 1.3-23.1, p=0.02) and obese men (OR=6.3, 95% CI: 1.6-31.1, p=0.009). Readmission within 6 weeks of surgery occurred in 35 (38%) men. Surgery was needed to treat long-term post UD complications in 19 (22%) patients with a median follow-up of 16.3 months.
UD after prostate RT has a considerable short and long-term surgical complication rate. Urinary diversion most often cannot be avoided in these patients, but appreciation of the risks allows for informed shared decision making between surgeons and patients.
Pharmacology, Toxicology and Pharmaceutical Science
2
4%
Engineering
2
4%
Veterinary Science and Veterinary Medicine
1
2%
Other
3
6%
Unknown
16
31%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 March 2019.
All research outputs
#3,142,228
of 32,304,778 outputs
Outputs from The Journal of Urology
#2,035
of 21,206 outputs
Outputs of similar age
#40,679
of 328,101 outputs
Outputs of similar age from The Journal of Urology
#39
of 330 outputs
Altmetric has tracked 32,304,778 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 21,206 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.5. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 328,101 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 330 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.
