@Nucleocapsoid @SolidEvidence There was a great paper by @GuptaR_lab showing that the Delta NTD enhanced S1/S2 cleavage and cell-cell fusion. It was dependent on the spike background, but I don't think it's a coincidence that we've seen several recombin…
Ryan addressing my query about likely functional roles of 180-loop mutations in Spike NTD that we now see in all the current fastest SARS-2 variants: F186L in LP.8.1.1 G184S in NB.1.8 K182R in LF.7 (and hence XFG) https://t.co/4Nno8nLrU5
@Nucleocapsoid @Asinickle1 @yunlong_cao They're all in an exposed NTD loop (#3 I think?), so I think they're just Ab-evading muts. The NTD affects S1/S2 cleavage, so these different NTD muts, even if they have ~equal Ab-evading effects, could have oth…
RT @LongDesertTrain: This deletion is unique to Delta & was likely quite important. @GuptaR_lab showed that Delta's NTD had a long-distance…