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Genetic recombination at different points in the Npro-coding region of bovine viral diarrhea viruses and the potentials to change their antigenicities and pathogenicities

Overview of attention for article published in Virus Research, October 2005
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Title
Genetic recombination at different points in the Npro-coding region of bovine viral diarrhea viruses and the potentials to change their antigenicities and pathogenicities
Published in
Virus Research, October 2005
DOI 10.1016/j.virusres.2005.08.016
Pubmed ID
Authors

K. Kameyama, Y. Sakoda, K. Tamai, M. Nagai, H. Akashi, H. Kida

Abstract

Cytopathogenic (cp) bovine viral diarrhea virus (BVDV) strain KS86-1 cp was isolated from a cow persistently infected with non-cytopathogenic (ncp) BVDV strain KS86-ncp after development of mucosal disease by superinfection with cp BVDV strain Nose. cp BVDV strains 799cp and 839cp were also isolated from independent cattle that developed mucosal disease by superinfection with cp BVDV KS86-1cp. In the present study, genetic analysis revealed that the genes of cp BVDV strains 799cp and 839cp were chimeras between the genes of the persisting ncp BVDVs and that of superinfecting KS86-1cp. The genetic recombination that generates 799cp occurred between the identical points in the N(pro) gene region, whereas genetic recombination that generates 839cp occurred between different points in the N(pro) gene region. Both 799cp and 839cp were inherited Jiv gene of KS86-1cp strain and envelope protein genes of the persisting viruses. In addition, neutralization test disclosed that antigenicities of 799cp, 839cp, and KS86-1cp were also similar to each persisting virus. These findings indicate that exogenous cp BVDV containing insertion of Jiv gene in the 5 terminal region can induce genetic recombination with the original ncp BVDV at different points in the N(pro) gene region, and those viruses have high potential to change those antigenicities and pathogenicities by RNA recombination.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 3%
Italy 1 3%
United Kingdom 1 3%
Mexico 1 3%
Denmark 1 3%
Japan 1 3%
Unknown 29 83%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 23%
Student > Bachelor 6 17%
Researcher 5 14%
Professor 3 9%
Student > Doctoral Student 3 9%
Other 4 11%
Unknown 6 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 13 37%
Veterinary Science and Veterinary Medicine 8 23%
Biochemistry, Genetics and Molecular Biology 2 6%
Immunology and Microbiology 2 6%
Medicine and Dentistry 2 6%
Other 0 0%
Unknown 8 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 August 2008.
All research outputs
#22,759,802
of 25,374,647 outputs
Outputs from Virus Research
#2,884
of 3,302 outputs
Outputs of similar age
#69,428
of 71,399 outputs
Outputs of similar age from Virus Research
#13
of 13 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,302 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.9. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 71,399 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.