You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Distinct Tumor Necrosis Factor Alpha Receptors Dictate Stem Cell Fitness Versus Lineage Output in Dnmt3a-Mutant Clonal Hematopoiesis
|
|---|---|
| Published in |
Cancer Discovery, September 2022
|
| DOI | 10.1158/2159-8290.cd-22-0086 |
| Pubmed ID | |
| Authors |
Jennifer M. SanMiguel, Elizabeth Eudy, Matthew A. Loberg, Kira A. Young, Jayna J. Mistry, Kristina D. Mujica, Logan S. Schwartz, Timothy M. Stearns, Grant A. Challen, Jennifer J. Trowbridge |
| Abstract |
Clonal hematopoiesis resulting from enhanced fitness of mutant hematopoietic stem cells (HSCs) associates with both favorable and unfavorable health outcomes related to the types of mature mutant blood cells produced, but how this lineage output is regulated is unclear. Using a mouse model of a clonal hematopoiesis-associated mutation, DNMT3AR882/+ (Dnmt3aR878H/+), aging-induced TNFα signaling was found to promote the selective advantage of mutant HSCs and stimulate production of mutant B lymphoid cells. Genetic loss of TNFα receptor TNFR1 ablated the selective advantage of mutant HSCs without altering their lineage output, while loss of TNFR2 resulted in overproduction of mutant myeloid cells without altering HSC fitness. These results nominate TNFR1 as a target to reduce clonal hematopoiesis and risk of associated diseases, and support a model wherein clone size and mature blood lineage production can be independently controlled to modulate favorable and unfavorable CH outcomes. |
X Demographics
The data shown below were collected from the profiles of 49 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 27 | 55% |
| France | 2 | 4% |
| Germany | 1 | 2% |
| Spain | 1 | 2% |
| United Kingdom | 1 | 2% |
| Ukraine | 1 | 2% |
| Portugal | 1 | 2% |
| Canada | 1 | 2% |
| Unknown | 14 | 29% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 21 | 43% |
| Members of the public | 20 | 41% |
| Science communicators (journalists, bloggers, editors) | 5 | 10% |
| Practitioners (doctors, other healthcare professionals) | 3 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 42 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 8 | 19% |
| Student > Ph. D. Student | 5 | 12% |
| Student > Postgraduate | 3 | 7% |
| Student > Master | 3 | 7% |
| Professor | 2 | 5% |
| Other | 5 | 12% |
| Unknown | 16 | 38% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 8 | 19% |
| Medicine and Dentistry | 6 | 14% |
| Immunology and Microbiology | 5 | 12% |
| Computer Science | 1 | 2% |
| Veterinary Science and Veterinary Medicine | 1 | 2% |
| Other | 2 | 5% |
| Unknown | 19 | 45% |
Attention Score in Context
This research output has an Altmetric Attention Score of 28. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2023.
All research outputs
#1,406,668
of 25,706,302 outputs
Outputs from Cancer Discovery
#719
of 4,148 outputs
Outputs of similar age
#30,690
of 438,041 outputs
Outputs of similar age from Cancer Discovery
#29
of 117 outputs
Altmetric has tracked 25,706,302 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,148 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 22.2. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 438,041 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 117 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.