Exercise has been shown to improve physical and psychosocial outcomes for people across the cancer care continuum. A proposed mechanism underpinning the relationship between exercise and cancer outcomes is exercise-induced immunomodulation via secretion of anti-inflammatory myokines from skeletal muscle tissue. Myokines have the potential to impair cancer growth through modulation of NK-cells and CD8+ T-cells while improving the effectiveness of cancer therapies. Interleukin-15, is one of the most abundant myokines found in skeletal muscle, has a key immunoregulatory role in supporting the proliferation and maturation of T-cells and natural killer cells which have a key role in the host's immune response to cancer. Furthermore, IL-15 is being explored clinically as an immunotherapy agent with doses similar to the IL-15 concentrations released by skeletal muscle during exercise. Here we review the role of IL-15 within the immune system, examine how IL-15 is produced as a myokine during exercise and how it may improve outcomes for people with cancer, specifically as an adjuvant or neoadjuvant to immunotherapy. We summarise the available evidence showing changes in IL-15 in response to both acute exercise and to training and the results are inconsistent; higher quality research is needed to advance the understanding of how exercise-mediated increases in IL-15 potentially benefit those who are being treated for, or who have had, cancer.
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 April 2023.
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#6,732,610
of 34,412,533 outputs
Outputs from Medicine and Science in Sports & Exercise
#3,514
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Outputs of similar age
#99,369
of 468,819 outputs
Outputs of similar age from Medicine and Science in Sports & Exercise
#35
of 61 outputs
Altmetric has tracked 34,412,533 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,591 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 26.3. This one has gotten more attention than average, scoring higher than 59% of its peers.
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We're also able to compare this research output to 61 others from the same source and published within six weeks on either side of this one. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.
