Genetic Variants Associated with Lp(a) Lipoprotein Level and Coronary Disease

Overview of attention for article published in New England Journal of Medicine, December 2009

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Genetic support for APOC3: https://t.co/HXkjZ8a8es https://t.co/BkZC0MEqtf https://t.co/xYFEOw1nji Genetic support for LPA: https://t.co/diYK4LpkqK https://t.co/MtIg6A65Il https://t.co/uRLTNKnDxg

@drterrysimpson No numerous trials including the all important Mendelian randomization studies have shown apoprotein (a) to be causal for ASCVD and Calcific aortic stenosis https://t.co/VCordrFkzt and https://t.co/t2oqkN0wlt https://t.co/JlptjLPIOU

LP(a) 脂蛋白（a）,是一种低密度脂蛋白变体，含有一种称为载脂蛋白（a）的蛋白质。遗传和流行病学研究已确定,脂蛋白（a）是动脉粥样硬化和相关疾病（如冠心病和中风）的危险因素

两种变体都与 Lp (a) 脂蛋白水平升高、Kringle 重复拷贝数减少，以及更危险的更小粒径密切相关。 5/8

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