Takehiko Yamanashi, Zoe-Ella Em Anderson, Manisha Modukuri, Gloria Chang, Tammy Tran, Pedro S Marra, Nadia E Wahba, Kaitlyn J Crutchley, Eleanor J Sullivan, Sydney S Jellison, Katie R Comp, Cade C Akers, Alissa A Meyer, Sangil Lee, Masaaki Iwata, Hyunkeun R Cho, Eri Shinozaki, Gen Shinozaki

Metformin has been reported to improve age-related disorders, including dementia, and to lower mortality. This study was conducted to investigate whether metformin use lower delirium risk, as well as long-term mortality. In this retrospective cohort study, previously recruited 1,404 subjects were analyzed. The relationship between metformin use and delirium, and the relationship between metformin use and 3-year mortality were investigated. 242 subjects were categorized into a type 2 diabetes mellitus (DM)-without-metformin group, and 264 subjects were categorized into a DM-with-metformin group. Prevalence of delirium was 36.0% in the DM-without-metformin group, and 29.2% in the DM-with-metformin group. A history of metformin use reduced the risk of delirium in patients with DM (OR, 0.50 [95% CI, 0.32 to 0.79]) after controlling for confounding factors. The 3-year mortality in the DM-without-metformin group (survival rate, 0.595 [95% CI, 0.512 to 0.669]) was higher than in the DM-with-metformin group (survival rate, 0.695 [95% CI, 0.604 to 0.770]) (p=0.035). A history of metformin use decreased the risk of 3-year mortality after adjustment for confounding factors (HR, 0.69 [95% CI, 0.48 to 0.98]). Metformin use may lower the risk of delirium and mortality in DM patients.