Beyond Microglia—Alzheimer’s Gene PLCγ2 Acts on Synapses, Too
Alzforum,
09 May 2024 The Alzheimer’s risk gene phospholipase C-γ2 has been thought to act mainly in microglia.
When Missense Variants Derail SORL1 Traffic, Destination Is Dementia
Alzforum,
18 Jul 2023 With its 2,214 amino acids and its dynamic lifestyle as an endosomal recycling receptor, SORL1 is rife with…
Study Finds Multiple Rare, Damaging Genetic Variants That Increase Alzheimer’s Risk - Health Reporter
Health Reporter,
Scientists at the Vrije University (VU) of Amsterdam have identified rare damaging genetic variants that increase Alzheimer’s…
AD文献阅读第10期：Nat Genet—ATP8B4 和ABCA1的罕见破坏性变异与阿尔茨海默病相关
CN-Healthcare,
他们的结果为AD中淀粉样β前体蛋白加工、淀粉样β聚集、脂质代谢和小胶质细胞功能的主要作用提供了新的证据。 中文摘要 阿尔茨海默病（AD）是痴呆症的主要原因，其遗传度估计约为70%。AD的遗传因子主要通过全基因组关联研究进行评估，这些研究没有发现罕见变异带来的…