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A review of adverse events caused by immune checkpoint inhibitors

Overview of attention for article published in Immunological Medicine, January 2016
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Title
A review of adverse events caused by immune checkpoint inhibitors
Published in
Immunological Medicine, January 2016
DOI 10.2177/jsci.39.30
Pubmed ID
Authors

Satoshi Fukushima

Abstract

  There has been no effective therapy in the unresectable melanoma for more than 40 years. Anti-PD-1 antibody and anti-CTLA-4 antibody have totally changed the situation. They have clearly shown the survival benefits of the patients with metastatic melanoma. However, immune checkpoint inhibitors sometimes induce various kinds of immune-related adverse events (irAEs). It is very important for the clinicians to know the reported cases of irAEs and to keep in mind the symptoms of irAEs for the early detection. This review describes the previously reported irAEs and adequate managements for irAEs induced by immune checkpoint inhibitors.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 2 5%
Unknown 41 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 16%
Other 5 12%
Student > Master 5 12%
Student > Ph. D. Student 3 7%
Professor > Associate Professor 3 7%
Other 7 16%
Unknown 13 30%
Readers by discipline Count As %
Medicine and Dentistry 14 33%
Pharmacology, Toxicology and Pharmaceutical Science 3 7%
Unspecified 2 5%
Biochemistry, Genetics and Molecular Biology 2 5%
Agricultural and Biological Sciences 2 5%
Other 4 9%
Unknown 16 37%