Over the years, scientists have studied the behavior and anatomy of many animals to understand our own species. However, despite our continuous efforts, it is often difficult to know for certain how our brain works due to the differences between the brains of animals and the human brain. While the use of animal models for research continues, the origin of human cognition and neurological disorders needs further elucidation. To that end, in vitro organoids that exhibit in vivo characteristics of the human brain have been recently developed. These brain-like organoids enable researchers to dive deeper into understanding the human brain, its neurological structures, and the causes of neurological pathologies. This paper reviews the recent developments in the regeneration of brain-like organoids using Matrigel and other alternatives. Further, gel-free methods that may enhance the regeneration process of organoids are discussed. Finally, the vascularized brain organoid growth and development in both in vitro and in vivo conditions are detailed. This article is protected by copyright. All rights reserved.
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 December 2022.
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#20,289,575
of 24,945,754 outputs
Outputs from Macromolecular Bioscience
#1,261
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Outputs of similar age
#345,499
of 473,244 outputs
Outputs of similar age from Macromolecular Bioscience
#20
of 27 outputs
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